Wednesday, December 12, 2012

Synthesis of Butyl Benzoate


Intro
The purpose of this experiment was to explore the methods by which a phase transfer catalyst facilitates the synthesis of the ester Butyl Benzoate from Sodium Benzoate and 1-Bromobutance. The full balanced molecular equation for the synthesis is NaC6H5CO2 + CH3CH2CH2CH2Br -> C6H5CO2CH2CH2CH2CH3 + NaBr.

How was it done?
First sodium benzoate was placed into a round bottom flask containing H2O. Next 1-Bromobutane, a boiling stone and Aliquat 336 were added to the same round bottom flask. The round bottom flask was fit with a reflux condenser and was set into a heating mantel attached to a variac set at 45%. Note the joints of the glassware were greased while keck clips and clamps were used to keep the glassware upright and stable. The mantel should be turned on and allowed to run for an hour under reflux conditions.
            After an hour the round bottom flask was removed from the mantel and cooled in room temperature water. The cooled contents were transferred to separatory funnel and the flask was rinsed with dichloromethane, which also went into the funnel. An additional 10 mL of dichloromethane were then added to the separatory funnel. The funnel was gently swirled and inverted the opening the stopcock to release pressure. The mixture was allowed to sit in a ring stand until 2 layers were visible.
            The lower organic layer was drained and placed into a clean labeled Erlenmeyer flask. The aqueous layer was poured out the top and placed into another clean labeled Erlenmeyer flask. The organic layer was transferred back into the separatory funnel where it was washed wit 5 mL of 15% NaCl solution. The lower organic layer was placed into the appropriate Erlenmeyer. Next anhydrous sodium sulfate was added to the Erlenmeyer with the lower organic layer (containing the ether) and was allowed to sit for 15 minutes.
            Meanwhile a 25 mL Erlenmeyer was washed, dried and weighed and Pasteur pipettes were fitted with cotton and prepared (shown left). The Pasteur pipette was used to transfer the organic solution into the newly cleaned Erlenmeyer.
            Next the dichloromethane was removed via a stream of nitrogen air while in a warm water bath.  Measurements of the weight of the beaker with contents were taken till two consecutive measurements are within .03 grams within one another. Once the weight was in the appropriate range the product was prepared for IR and checked for evidence of the product.

Results, Questions, Calculations and stuff like that...

Limiting reactant: There is a 1:1 molar ration of 1-Bromobutane to Sodium Benzoate. The experiment used 2.0 mL of 1-Bromobutane with density 1.27 grams / mL = 2.54 grams of 1-Bromobutane. Compared to the 3.05 grams of sodium benzoate. Hence 1-Bromobutane is the limiting reagent.

Theoretical Yield

__g 1-Bromobutane x 1 mole 1-Bromobutane x 1 mole Butyl benzoate x 178 grams   =  ____ g Butyl benzoate expected
                                    137 grams                  1 mole 1-Bromobutane    1 mole Butyl benzoate
  
Percent Yield

Observed yield     x 100%  = ______%
Expected yield   
 
Infrared spectroscopy absorption bands of significance
Major Absorption peak or band
Suggested reason for peak
Functional group
Strong peaks near 1600 and 1500-1430
C6H5  Benzene ring
Benzene ring
Activity between 1602 and 1782
C=O
Carbonyl
Strong peaks between 1070 and 1274
C-O
Ether
Strong peaks near 2850-2959
C-C-H
Carbon Hydrogen stretching vibration

Carbon-13 Nuclear magnetic resonance imaging results
Peak in ppm
Significance
13.8345
Methyl (CH3)
19.3615
CH2
30.8584
CH2
64.8986
 C-O
76-77
CDCl2
128.3910
Aromatic Carbon
129.6049
Aromatic Carbon
130.6125
Aromatic Carbon
132.8722
Aromatic Carbon
166.7674
 C=O

Proton Nuclear magnetic resonance
Approximate ppm
Splitting
Integration
Group Significance
.99
Multiplet
3
CH3
1.4
Multiplet
2
CH2
1.7
Multiplet
2
CH2
4.3
Triplet
2
CH2 expected to be near electron withdrawing group
7.4
Multiplet
2
In monosubstituted benzene ring
8.0
Multiplet
2
In monosubstituted benzene ring

DEPT analysis
Approximate Peak location ppm
Positive or negative region
Potential significance
11
Positive
CH3
29
Negative
CH2
64
Negative
CH2
128
Positive
CH most likely in aromatic region
130
Positive
CH most likely in aromatic region
132
Positive
CH most likely in aromatic region
 
As indicated by Infrared spectroscopy it is clear that the yielded product obtains a Benzene ring and has activity in regions associated with carbonyl and ether functional groups. The data from the Infrared spectroscopy also suggests that there is a carbon chain in the product. The data from the Carbon 13 Nuclear magnetic resonance imaging results suggests that there is a Carbon double bond with oxygen (C=O) and a Carbon Oxygen single bond (C-O). Absorption peaks near 130 ppm indicate Carbons in an Aromatic ring while the more upstream peaks suggest the presence of CH2 and CH3 most likely in a Carbon chain. Proton Nuclear magnetic resonance and DEPT analysis suggest a monosubstituted benzene ring is in the product and the presence of multiplets in the spectrum suggests that there are neighboring unequivalent Carbons attached to hydrogen and suggests electron withdrawing groups that increase deshieleding. Overall data collected from the spectra support the expected result of Butyl Benzoate being synthesized from 1-Bromobutane and Sodium Benzoate via use of the phase transfer catalyst.


 

Sunday, November 4, 2012

How to get a dollar sent to your house for free!

Okay so this isn't organic chemistry...but everybody loves cash...right? Right now there an offer where you can get a dollar (US) sent to your place of residence. The instructions go as follows....

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 1) sign up at this website.



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Sunday, August 19, 2012

Color and Para Red

In this post I'll talk about a little chemistry regarding color(s) and Synthesis of the Dye Para Red from Aniline

First some info from WIKI:
Para Red (paranitraniline red, Pigment Red 1, C.I. 12070) is a chemical dye. Chemically, the dye is similar to Sudan I. The dye was discovered in 1880 by von Gallois and Ullrich, and was the first azo dye. It dyes cellulose fabrics a brilliant red, but is not very fast. The dye can be washed away easily from cellulose fabrics if not dyed correctly. Throughout making Para Red, the solution will become acidic and basic. Small amounts of byproducts may be left over after the Para Red dye is made that may be acidic or basic, but if made correctly there are little of these and the byproducts have no effect.
In the United Kingdom, the dye is not permitted in food. The UK's Food Standards Agency (FSA) stated that "the Agency’s independent scientific experts have advised that, although there are very limited data available, it would be prudent to assume that it could be a genotoxic carcinogen". [2]
On 21 April 2005, the FSA announced that some batches of Old El Paso dinner kits had been contaminated with the dye, and issued an alert.[2] Also, reported on the 5 May 2005, the dye was found in 35 products which have now been taken off supermarket shelves. The products were mainly cooking sauces, though some are also spices.[3]





At this point I'm going to ask you please please please yo help me out and check out these sites below if you appreciate the help here! 




Procedure
             All procedures were carried out under a hood, all individuals involved wore nitile gloves and safety goggles. Glassware was cleaned, rinsed with deionzed water and if necessary acetone before usage.
            First .7 grams para-Nitroaniline, 15 mL H2O were placed in an Erlenmeyer  flask. The flask was placed onto a hot plate and 3 M HCl was added till everything was completely dissolved. Upon dissolving the solution was cooled in ice water bath (0-5°C) for 10 minutes. Meanwhile a solution of 7 % NaNO2 was prepared by adding .7 grams NaNO2 to 10mL H2O and swirled for 10 minutes with stir bar via the use of the stir function on the hot plate. The heating function was turned off on the hot plate and the solution was kept cool during the period of the stirring.
            Next .7 grams KI were weighed and placed in a beaker. Via the use of a pipette 5.0mL of the cold diazonium salt was added to the KI. The mix was swirled till gas evolution decreased and then ceased. The solid was isolated via vacuum filtration with a Hirsch funnel and washed twice with 1mL portions of cold deizonized water. After filtration the product was isolated and kept for a week allowing it to dry.

            In another 50 mL beaker .25 g b-naphthol and 15mL water were heated till about 60-80°C. Next 10% NaOH was added drop wise will all was dissolved. Meanwhile a notch was cut in the wool portion of the fabric (to help with identification). The fabric was soaked in the solution for about 2 minutes, then removed with forceps and patted dry. The fabric was then placed in the cool diazonium salt.
            Once the fabric was removed the remainder of the b-naphthol was chilled till about 5°C. After cooling the remainders of the 2 solutions were mixed together and via the use of a Buchner funnel underwent vacuum filtration. The collected product was washed thoroughly with water. Once the product was collected it was placed in a beaker and allowed to sit for a week to dry. After the products dried the melting point range was observed and analyzed

For more go here:

https://docs.google.com/viewer?a=v&q=cache:lravLKFHs34J:ochemonline.pbworks.com/f/04_Azo_Dyes.pdf+&hl=en&gl=us&pid=bl&srcid=ADGEESglnTd8VLb0HroH3tQxK2VX1Fqbdyj_WYOKBfIA2Uvw5Gq-VdBtjmuoJJu6eHNr-uqF0-0DssQbyG2VMXEdm2HHPlQKX2Cvoy3MWk5AJZ9mzEiCRfntPakhtnKTtvC8woqy3GdW&sig=AHIEtbSwxqlxEJSBGwZDfD6wYRa-rKJXYg&pli=1

Sunday, June 10, 2012

So you have a chemical unknown...

Feel free to try this out if you have a chemical unknown it might help! Organic Compounds Database

Welcome to the Organic Compounds Database.

This 2483 compound database has been compiled by Harold M. Bell at Virginia Tech. Fill in the form below with as much information as you can. Leave the information blank if you don't know or you don't care. Click on the submit button to execute your search. You will receive at most 20 hits.
Melting Point +-5C________________ Boiling Point +-5C
Index of Refraction, nD20 +-0.005_ Molecular Weight +-2amu
Formula: C H N O Cl Br I S
(for formulas you can enter a ">" or "<" in front of the number, eg. >2)

UV Absorption Wavelengths:

, , +-5 nm

Mass Spectral Peaks:

, , , m/e

Chemical Types:

No Carbonyl present_ Carbonyl present
No Aromatic present_ Aromatic present
No OH or NH present OH or NH present
CH type:
no C-H saturated C-H unsaturated C-H both saturated and unsaturated C-H Compound name contains:
Key to the Literature References
This data is available with 2D-structures and NMR chemical shifts in ISIS/Base format.

Friday, April 27, 2012

Bromination of trans-cinnamic acid




In this lab we'll look at what its like to add bromine to transcinamic acid via adding methods of stereo-chemistry. Additionally we'll take a look at trying to prove the reaction was successful and that we actually did get 2,3-dibromo-3-pheylpropanoic acid.Bromination are a type of Halogenation procedures using bromine, read more about it here.





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 Below is kind of a generalized look at the addition of the Bromine via a Trans Addition, which sorry to spoil the surprise is the way its going to add.


Trans-cinnamic acid (E-3-phenyl-2-propanoic acid) has a molecular weight of 148 g/mol and a melting point of 133 degrees Celsius.

There are several enantiomers of 2,3-dibromo-3-phenylpropanoic acid, they all have a molecular weight of 308 g/mol (Molecular Weight: 307.96662 to be specific).

The (2R, 3S) and (2S, 3R) have a melting point of 202-204 degrees Celsius.

The (2R, 3R) and (2S, 3S) have a melting point of 93.5 to 95 degrees Celsius.



 Things that were done:

150 mg trans-cinnamic acid and .6 mL glacial acetic acid were put acid in a test tube. The tube was put in a 50 degree celcius water bath till all the trans-cinnamic acid dissolves. Next 1.0mL of 1.0M Br2 in acetic solution. the mix was stirred via agitation at 50 degrees Celsius till the color faded from red/brown to light orange and was heated for another 15 minutes. Next a drop of cyclohexane was added. The mix was cooled in ice water bath for 10 minutes (crystals formed). Meanwhile distilled water was cooled (in an ice bath). Note if the crystal didn't form the side would have been scratched with a siring rod and left in the ice water bath for another ten minutes.

The product was collected via vacuum filtration. The crystals were washed with ice water ( note its a good idea to do it till the smell of acetic acid is gone. Next was the process of recrystallization. The sample retrieved from vacuum filtration was placed in .5mL ethanol in an 10mL Erlenmeyer flask. After the sample had dissolved boiling stick was added and the mix was heated via a steam water bath. If the sample doesn't dissolve add more ethanol. Next a volume of water equal to the amount of ethanol was added. The sample was removed from the heat and allowed to cool for 10 minutes in ice. Crystals were removed from the solution via vacuum filtration (note a new clean Hirsch funnel and new filter paper was used)

 Things you may ask...

What is a mixed solvent recrystallization? What is the reason for using mixed solvent recrystallization?

 Mixed solvent recrystalization refers to a process of crystallization used for the purpose of purification. A solvent is added to a mixture with desired and undesired components creating a solution. The solution is heated so that all of its components are able to dissolve, this solvent chosen because of its known properties of solubility. At a higher temperature everything should remain dissolved in the solvent as it becomes supersaturated. However as it cools crystals of your desired compound should form being that at lower temperatures the solvent can no longer remain super saturated, meanwhile impurities and undesired compounds should remain dissolved in the solvent. In this experiment the crystals could be isolated via vacuum filtration.

 Should the product exhibit optical activity?

 No the product would not exhibit optical activity because while each enantiomer is chiral they exist as a racemic mixture such that the specific rotation of one enantionmer would cancel the rotation of the other being that they should have the same magnitude but in the opposite direction.

 What is the mechanism of the addition like?



It can happen via Radicals
What can the melting point/range say about the purity of the sample?

 If the observed melting point or range is near the reported melting range from the literature it suggests that  the product is that of the enantiomer set. For this particular experiment the  (2R,3S) and (2S, 3R) enantiomers of 2,3-dibromo-3-phenylproanoic acid are expected. Indicating that the bromine addition occurred via an anti method. Had bromine of added via syn addition the melting point would have been near 95 °C (provided in the literature).  The difference of several degrees between the literature and the experimental values may be the result of impurities and the possible existence of other enantiomers or compounds in the product. Recall that impurities cause depression and extend the range of the melting points.



Tuesday, April 17, 2012

Fun?

Please excuse the dorkish moments...

Meet Metta World Peace formerly known as Ron Artest.


 Shall we go to Paradise?

 Because ortho sounds like some root word related to bones, here is another one.





Some more attempts at funny.








Sunday, April 15, 2012

Limonene

Limonene exists in R-(+) and S-(-) formations. Both have a boiling point of 175.5-176 degrees Celsius, both have a molecular weight of 136.2 grams per mol but they differ in their optical rotation. 

R-(+) has a density of about .8402 g/mL and an optical rotation of 125.6 degrees (note the positive number) while the S-(-) has a density of .8407g/mL and an observed optical rotation of -122.1 degrees (note the negative number)

In this lab we'll talk about Isolating the R-(+) formation of Limonene from orange peels. Note the R-(-) can be found in Caraway seeds.

How you do it?
Take the oranges and peel them. It's best to do this right away to prevent the loss of limonene. Try to remove the white pulp from the peel.

In a blender add the peels and 200- 250 mL of water. After blending put in a 500 mL round bottom flask. Add 4 drops of anti foaming agent...or don't if you would like to have a "fun time". With a Claisen adapter prepare for steam distillation with a 50 mL round bottom flask as the receiver. Marking the 50 mL round bottom flask at the 35 mL level will be helpful so pour some water in it, mark it, empty it and voila.

Boil the mix without letting any solid material bump over into the condenser. Collect 35 mL of the distillate. Note if you use a heating mantel a variac will probably be a good idea as to add an element of control. Also it will prevent the mantel from heating up to quickly/getting to hot and in the process you may actually end up burning your orange peels. Burning the orange peels may result in bad results and a load of gunk that accumulates on the bottom of the round bottom flask which take my word will be annoying and nasty to clean up however a bit of acetone, some soap and some time will help you eventually make it clean again. Also the burned peels may affect your observed optical rotation adding an element of impurity to the sample.

Pour the distillate into a separatory funnel (125 mL size should do). Add 5 g sodium chloride and shake. Next add 10 mL dichloromethane via a conical funnel through the top of the separatory funnel. Gently shake the mix and allow for pressure to be release by opening the stop cock every so often. Let the mix sit and the layers to separate. Make sure the stop cock is closed during this process and the stopper is held is place or else by by sample.
Collect the bottom layer (the organic bottom layer and the top is the top aqueous layer) in a flask. Repeat the extraction with 15mL dichloromethane (fresh) every time. Next dry the extracted solution with anhydrous magnesium sulfide for 10 min.
Meanwhile weight and clean an Erlenmeyer flask for later use. Into this Erlenmeyer with the use of a conical funnel fitted with filter paper and pour the solution. This should take out the anhydrous magnesium sulfide.

Then by any means you want be it nitrogen gas, hot water bath or just allowing it to sit allow the dichloromethane to evaporate.

To do polarimetry (link should take you to wikipedia) obtain 10mL of 95% ethanol. Dissolve Limonene in 3 mL of the ethanol via Pasteur pipette. Transfer to a 10mL volumetric flask and do polarimetry on it. Note calculate the polarimeter with the 95% ethanol as the reference solution. The rotation should tell you about entantiomeric excess if applicable.


Questions:

 What is a steam distillation?  Why is it useful in this isolation experiment?

            Steam distillation is a form of distillation often used to distill heterogeneous mixtures. It allows for the adding of pressures of components in the mixture to overcome that of the atmosphere and boil. This typically results in lower temperatures till boiling is reached especially so when compared to a solution that follows Raoults Law.

            Steam distillation is useful in this experiment because it lowers the temperature necessary to give rise to the boiling of limonene. Typically to achieve this point the boiling point would be so high the orange peels would burn and the charring would contaminate the isolated limonene. The H20 and limonene pressures combine give rise to the lowered boiling point. It’s also possible that higher temperatures would result in decomposition of limonene.

 What was the purpose of the extracting of our collected distillate with dichloromethane and salt-water?

            The salt in the salt water allows for more transfer of limonene to the organic layer. The salt is absorbed in the water and saturates it decreasing the total possible amount of limonene that can be absorbed by the water. Similar to a process called "salting out".
            If the dichloromethane was used for extraction the Limonene would have been found in this layer. Because dichloromethane is more dense than water and they do not mix the dichloromethane would have formed a visible layer below the water that could be taken out by opening the stop cock of the separatory funnel and allowing the bottom layer to be collected.

How do I find the specific rotation?

specific rotation = observed rotation                                                                       
                               (density in g/mL) x length of polarimeter tube in decimeters

Or in words its the observed rotation divided by the product of the density (aka concentration) and the length of polarimeter tube in decimeters.

What happens if you shake too vigorously during the extraction with dichloromethane?

The gas could explode due to the build up of pressure inside of the separatory funnel. Also you may mix the layers so well that it won't separate as quickly.


On the other hand what happens if you don't shake vigorously enough?
The layers may not separate and limonene may not separate from the aqueous layer and go into the dichloromethane layer.

As always I don't get paid for this so if you can please join below I really appreciate it.

Friday, April 13, 2012

Alcohol...lets make some.

So this isn't the best way to make alcohol I guess but still never the less its alcohol...lets make some. Specifically we will be synthesizing ethanol by fermenting sucrose with the help of some yeast. Ethanol is also known as Absolute alcohol, Alcohol, Drinking alcohol
Ethyl alcohol, Ethyl hydrate, Ethyl hydroxide, Ethylic alcohol, Ethylol, Grain alcohol, Hydroxyethane, Methylcarbino. Go here to learn about ethanol.

General Information:

What we are going to talk about.
C2H22O11 plus H2O breaks into 2 C6H12O6 plus zymase gives us 4 CH3CH2OH (ethanol) + 4 CO2


Place 40 mg sucrose in a 500 mL Erlenmeyer, add 200 mL water and 3.0 g dry yeast. Stire till sugar dissolves and you can't really see the yeast.

Add 35 mL Pasteurs salt - stir to mix. Close the flask with a stopper fitted witha  piece of bent glass tubing.

Fill a test tube halfway with a saturated Ca(OH)2 (also known as limewater) - submerge other end of glass tube into test tube so its about 1 cm below surface of the solution. Store for a week.

After a week come back and filter the solution via vacuum filtration in a 500 mL filter flask. Rinse flask with water. Now take the filtrate in the Erlenmeyer and place in a round bottom flask, add 2 boiling stones and assemble for simple distillation. Set so the Alcohol flows into the recieving flask at 1 drop/sec. Heat till 50 mL are collected.

To find the density of this weight a tared 10.0 mL erlenmeyer, add 10.0 mL of the distillate and mass/volume = density which corresponds with a percent alchol by volume.

Take the sample (all of the simple fractional distilation sample) and prepare for fractional distillation. Use a 100 mL round bottom flask, add some boiling stones. In the Fractional distillation either pour some glass beads or stainless steel sponge. Turn heat to moderate amount and wait.  Collect 3 different samples each called Fraction 1, 2, 3 etc.

Fraction one should be the first 10 mL sample, Fraction 2 is the sample from 78 to 80 degrees Celcius and Fraction 3 is really rubish.

To determine the percent alcohol by volume or by mass use the same technique as above. Take a known volume, find its mass. Mass divided by volume = density. Use tables or online literature valus to find the percent alcohol by volume by the corresponding density. Remember water is more dense than alcohol. Hence water sits below alcohol if you pout them together. Ideally you would want your sample to weigh less.

Questions

What does the density and percent composition results tell you about the relative efficiencies of simple vs. fractional distillation? In other words, the distillation efficiency is higher when the distillate density is _________ and percent ethanol is ______________.

Blank 1) lower Blank 2) higher

Distillate from simple distillation does not have as high of percent alcohol as those of fractional distillation, hence fractional distillation has a higher efficacy. When distillation efficacy is higher the density of the solution is lower and its alcohol content is greater.

2. Which method gives purer ethanol? Briefly explain reasons for the difference in efficiencies of these two distillation methods, assuming no large technical errors were made.

Fractional distillation should result in purer ethanol. The difference is in part due to difference in apparatus, which provides more surface area to allow for cooling and condensation of the sample, the increase in plates and allow to get closer to the azeotrope.

3. How does the recorded temperature relate to the composition of the distillate?

The lower the boiling point of the solution the greater the likelihood that there is more ethanol in the solution. Ethanol has a lower boiling point than water, hence it is more volatile. Temperature and composition are directly related because the boiling point is contingent upon the compsition of the solution and the more volatile substances boil first.


4)What is an "Azeotrope"?
Its where you have liquid and vapor with same boiling point so no more enrichment can occur via distillation.

5) What makes fractional distillatation more efficient that simple distillation in terms of the aparatus. Being that in this case the two liquids have a similar boiling point.

The distillation column makes fractional distillation more efficient. Its filled with glass beads or steel wool. This elongated column allows for more surface area fr vapor to become cool and in liquid form again. Then it heats up again. Allowing for more plates (cycles of warming to vapor and being cooled again).
In each plate (heating till vaporazation till cooling and retuning to liquid form via condensation) in falls down back the fractional distillation tube the percent alcohol actually increases till the azeotrope is reached because both liquids have simlar boiling points they go through the same states.

Check out this image it may help.


Anyways if you are bored and or broke as always go here: